NBC News projects that incumbent Republican Roger Wicker will pull out a win against former Governor Ronnie Musgrove in Mississippi.
With Kentucky's McConnell, Mississippi's Wicker, and Georgia's Chambliss - who looks positioned for reelection - Senate Democrats won't reach 60 votes, even if they gain seats in Colorado (Udall) and Alaska (Begich).
The two races still very much up for grabs: Minnesota and Oregon. But even with those potential victories, Democrats are poised to fall just short of the sixty votes needed for a filibuster-proof majority in the US Senate.
Nebraska's new senator, as expected, will be Mike Johanns.
Johanns, the former Secretary of Agriculture to Bush, will join Sen. Mel Martinez, former HUD director, as the second former Bush Administration cabinet member in the Senate.